Two questions Gemzar Abraxane

[Vasil]

Hi all. I have two questions regarding treatment with Gemzar Abraxane. Has anyone experienced an initial increase in CA 19-9 and then gradual decrease. In my father's case this marker rose from 6k to 10k after the first session and then stuck at 10k although it's been a month of weekly treatment so I am wondering if it's going to drop down at all.

And my second question is about third line treatment. Has anyone had a further treatment after successive failure of Folfirinox and Gemzar Abraxane.

 

Thank you so much.