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NanoKnife for stage IV inoperable?


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Has anyone heard of irreversible electroporation NanoKnife applied to a metastatic PC that is also inoperable? Surgeons usually say surgery for stage IV makes no sense since it does not increase survival. And yet... Does anyone have any idea? They say this procedure is supposed to spare the surrounding tissues like arteries and veins involved.

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PCUK Nurse Rachel R

Hi Vasil,


It's Rachel here again. Thanks for your questions. I'm sure some people will offer their thoughts here soon. In the mean time though if you did wish to contact us on support line we would more than happy to discuss these things with you.


Best wishes, Rachel


Rachel Richardson

Pancreatic Cancer Specialist Nurse

Support Team

Pancreatic Cancer UK

email: nurse@pancreaticcancer.org.uk

support line: 0808 801 0707

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I would like to ask the same question as Vassel, as unfortunately i have exactly the same problem. can anyone help or suggest good or bad about nanoknife PLEASE

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Dear Peter, I have been reading lots of oncology articles recently. Opinions seem to diverge. Officially metastatic PC is not subject to any kind of surgery since this would in no way prolong survival (so they say). But the decision depends on the surgeon and the treating institution. For instance some of these articles allow for NanoKnife even in case of metastasis provided the secondary tumors are not very large (i.e. lesser than 3-4 cm in size). So we are hoping for this kind of procedure. Researches done on irreversible electroporation for stage IV PC claim to have achieved median survival of 2 years which is double the 11 months guaranteed by Folfirinox alone.


My father has peritoneal mets only, the largest being 3 or 4 cm and near the spleen. What about you? Have you undergone any sort of neoadjuvant treatment? Is NanoKnife common in the UK? BEST REGARDS, VASIL

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